Louis Wain was an artist in the late 1800s who started painting cats to entertain his ailing wife, who suggested he send them out to magazines and newspapers. This was the start of the Louis Wain Cat, a cartoonish image which became very popular both in Britain in America. Shortly after the cat became famous, Louis began to succumb to schizophrenia, and you can see the progression of his breakdown in the drawings.

Late Onset - Louis Wain
Via Digg